Umbefu yimeko yokuphefumla engapheliyo ephawulwa kukudumba kunye nokuncipha kwendlela yomoya, ekhokelela kubunzima bokuphefumla, ukuphefumla, ukukhohlela, kunye nokuphefumla nzima. Unyango oluqhelekileyo, olufana ne-inhalers kunye ne-bronchodilators kunye neyeza ezichasayo, zinceda ukulawula iimpawu ze-asthma. Nangona kunjalo, kukho umdla okhulayo kumandla e-cannabis kunye nee-cannabinoids zayo zokubonelela ngesiqabu kubantu abane-asthma. I-Cannabis iqulethe iindidi ze-bioactive compounds, ngokugqithiseleyo i-cannabinoids, ebonise iziphumo ezithembisayo ekulawuleni iimpawu ze-asthma kunye nokujongana nezizathu eziphambili zesifo. Eli nqaku liphonononga izibonelelo zokusebenzisa i-cannabis kwi-asthma, ireferensi yophando oluthile kwaye iqaqambise i-cannabinoids ebandakanyekayo kwezi zifundo.
I-Cannabinoids: Abadlali abaphambili kuPhando lwe-Asma
I-Cannabis iqulethe ngaphezu kwe-100 eyahlukeneyo ye-cannabinoids, kodwa ezona ziyaziwa kwaye ziphandwa yi-tetrahydrocannabinol (THC), i-cannabidiol (CBD), kunye ne-cannabigerol (CBG). Nganye kwezi cannabinoids zisebenzisana nenkqubo ye-endocannabinoid yomzimba (ECS), edlala indima ebalulekileyo ekulawuleni ukuvuvukala, ukuphendula komzimba kunye ne-homeostasis.
I-Tetrahydrocannabinol (THC): I-THC iyona nto iphambili ye-psychoactive compound kwi-cannabis, eyaziwa ngokukwazi ukuvelisa "phezulu" xa idliwe. Nangona kunjalo, i-THC ikwafunyaniswe ineempembelelo zokuchasa ukudumba kunye ne-bronchodilatory, enokuthi incede abantu abane-asthma ngokuphumza izihlunu ezigudileyo kwi-airways kunye nokunciphisa ukudumba.
I-Cannabidiol (CBD): Ngokungafaniyo ne-THC, i-CBD ayisebenzisi ingqondo kwaye iya isaziwa ngakumbi ngenxa yokuchasana nokudumba, i-analgesic, kunye ne-anxiolytic properties. I-CBD ibonakalise amandla njengonyango lwe-asthma ngenxa yokukwazi ukumodareyitha amajoni omzimba, ukunciphisa uxinzelelo lwe-oxidative, kunye nokukhusela ekudumbeni kwendlela yomoya ngaphandle komngcipheko wokunxila.
I-Cannabigerol (CBG): I-CBG, edla ngokubizwa ngokuba "ngumama wazo zonke i-cannabinoids," isandulela se-THC kunye ne-CBD kwisityalo se-cannabis. Ngelixa ifundwe kancinci, i-CBG ibonise amandla ekudambiseni ukudumba kwaye inokuba neziphumo zebronchodilator, icebisa ukuba kunokuba luncedo ekunyangeni iimpawu zesifuba.
UPhando oluPhambili kunye neziphumo
Izifundo ezininzi ziye zaphonononga iingenelo ezinokubakho ze-cannabis kunye ne-cannabinoids ye-asthma, kugxilwe ngakumbi kwi-THC, i-CBD, kunye neziphumo zabo zokuchasa ukudumba. Ngezantsi ziziphumo zophando eziphawulekayo:
I-THC njengeBronchodilator: Uphononongo olungoovulindlela olwenziwa kwi-1970 nguDkt Donald Tashkin kwiYunivesithi yaseCalifornia, eLos Angeles (UCLA), ihlolisise imiphumo ye-THC kwizigulane ze-asthma. Uphononongo lufumene ukuba ukuphefumla i-THC kubangele i-bronchodilation (ukwandiswa kweendlela zomoya), okwavumela abathathi-nxaxheba ukuba baphefumle ngokulula. Imiphumo ye-THC yayifana namayeza esintu e-asthma, njenge-beta-agonists, esetyenziselwa ukukhulula imisipha ejikeleze i-airways kunye nokwenza lula ukuphefumla. Oku kufunyanisiweyo kucebise ukuba i-THC inokuba lukhetho oluluncedo lonyango kwizigulana ezinesifo sombefu, ngakumbi kunyango oluqatha.
Iimpembelelo ze-CBD ezichasayo: Uphando olupapashwe kwi-Journal of Clinical Investigation (2013) lubonise ukuba i-CBD ineempawu ezichasayo, ezinokuthi zincede abantu abane-asthma. Uphononongo lufumene ukuba i-CBD ithintele ukukhutshwa kwe-cytokines e-pro-inflammatory, eyiamolekyuli ezibandakanyekayo kwimpendulo ye-immune kunye nokudumba. Isifuba somoya sibonakaliswa kukudumba okungapheliyo kweendlela zomoya, kwaye ukukwazi kwe-CBD ukulungelelanisa ukudumba kunokunceda ukunciphisa ukuxinana kwendlela yomoya kunye nokuphucula ukusebenza kwemiphunga ngokubanzi.
I-Cannabinoids kunye ne-Immune System Modulation: Uphononongo olupapashwe kwiBritish Journal of Pharmacology (2011) luhlolisise imiphumo ye-cannabinoids kwi-immune system. Uphando lwafumanisa ukuba i-THC kunye ne-CBD zombini zinamandla okuguqula iimpendulo zomzimba ngokuchaphazela iiseli zokuzivikela ezifana neeseli ze-T-helper kunye ne-macrophages. Olu hlengahlengiso lubaluleke kakhulu kwi-asthma, apho isistim somzimba esisebenza ngokugqithisileyo sibangela iimpendulo ezivuthayo kwimiphunga. Ngokunciphisa impendulo yomzimba, i-cannabinoids inokunceda ukukhusela ukuhlaselwa kwe-asthma kunye nokuvutha.
I-CBG kunye ne-Airway Inflammation: Nangona kungakhange kufundwe ngokubanzi njenge-THC kunye ne-CBD, i-CBG ibonise isithembiso kwizifundo zangaphambili kwimiphumo yayo yokuchasana nokudumba. Uphando olupapashwe kwi-Future Medicinal Chemistry (2017) lucebise ukuba i-CBG inokunciphisa ukuvuvukala kwi-airways ngokusebenza kwii-receptors ezithile ezibandakanyekayo ekudumbeni. Esi siphumo sinokuba luncedo ngakumbi kwizigulana ze-asthma ezifumana ukudumba okungapheliyo kwityhubhu ye-bronchial.
Ukudityaniswa kweCannabinoids: Uphononongo lwe-2016 kwi-European Journal of Pharmacology luhlolisise iziphumo ze-synergistic ze-THC kunye ne-CBD ekunciphiseni ukuvuvukala nokuphucula ukusebenza kwemiphunga. Uphononongo lufumanise ukuba indibaniselwano yazo zombini i-cannabinoids ibonelela ngezibonelelo zonyango ezinkulu kune-cannabinoid yodwa, exhasa umbono wokusetyenziswa konyango olupheleleyo lwe-cannabis ukulawula iimpawu ze-asthma. Esi siphumo se-synergistic sinokukhokelela kulawulo olungcono lokudumba, ukuxinana kwendlela yomoya, kunye nezinye iimpawu zesifuba.
Ukusetyenziswa kweKlinikhi yeCannabis kwi-Asma
Ngelixa uphando nge-cannabis ye-asthma lusekwinqanaba lokuqala, iziphumo zikhokelele kwizicelo ezininzi zeklinikhi ezinokubakho:
Iinhalers kunye neVaporizers: Ukukhupha i-cannabis okanye ukusebenzisa i-inhalers efakwe kwi-cannabinoid ingaba yindlela efanelekileyo yezigulane ze-asthma ukufumana izibonelelo zonyango ze-cannabinoids. Ukuphefumla kuvumela i-cannabinoids njenge-THC kunye ne-CBD ukuba zichaphazele ngqo iindlela zomoya kwaye zinike isiqabu ngokukhawuleza kwiimpawu. I-vaporization ikhethwa ngaphezu kokutshaya kuba inciphisa izinto ezinobungozi ezinokucaphukisa imiphunga.
Ioli yeCannabinoid kunye neTinctures: Kubantu abangakwaziyo ukunyamezela ukutshaya okanye ukufunxa i-cannabis, ioli ye-cannabinoid okanye i-tinctures inokubonelela ngenye indlela yokuhambisa. Ezi mveliso zinokungeniswa ngomlomo okanye zithathwe ngaphantsi kweelwimi ukunika iziphumo ezihlala ixesha elide. I-oyile ye-CBD, ngokukodwa, iye yaduma ngenxa yeempawu zayo ezingezizo zengqondo kunye nokukwazi ukunciphisa ukuvuvukala ngaphandle kokunyusa "phezulu."
Usetyenziso lwezihloko: Nangona ngaphantsi ngokuthe ngqo kwi-asthma, iimveliso ze-cannabis-based based based products, ezifana ne-balms okanye i-creams, zinokunceda ukulawula ukuvuvukala kwisifuba okanye kwindawo yentamo, ukunika ukukhululeka kwi-muscle okanye ukuqina okubangelwa ukuhlaselwa kwe-asthma.
Imingcipheko enokubakho kunye nokuqwalaselwa
Ngelixa izibonelelo ze-cannabis ze-asthma ziyathembisa, kubalulekile ukuqaphela eminye imingcipheko enokubakho kunye nokuqwalaselwa:
Ukucaphuka kweAirways: Ukutshaya okanye ukuphefumla i-cannabis kunokucaphukisa iindlela zomoya, ezinokuthi zibe mandundu iimpawu zesifuba kwabanye abantu. Yiyo loo nto i-vaporization, ebandakanya ukufudumeza i-cannabis ukukhulula i-cannabinoids ngaphandle kokuyitshisa, ihlala icetyiswa ngaphezulu kokutshaya.
Iziphumo zengqondo: I-THC inokuvelisa imiphumo ye-psychoactive, enokuthi ingafaneleki kuzo zonke izigulane ze-asthma, ngakumbi ezo zineemeko ezithile zangaphambili okanye uvakalelo. Nangona kunjalo, iimveliso ezinomxholo ophezulu we-CBD kunye nokugxila okuphantsi kwe-THC kunokubonelela ngeziphumo zonyango ngaphandle kwemiphumo ebalulekileyo ye-psychoactive.
Ukunqongophala kweDosing esemgangathweni: Ngenxa yokwahluka kwamandla emveliso ye-cannabis, ukumisela idosi echanekileyo yolawulo lwe-asthma kunokuba ngumngeni. Izigulana kufuneka zisebenze ngokusondeleyo nababoneleli bezempilo ukuze bafumane idosi efanelekileyo elawula ngokufanelekileyo iimpawu ngaphandle kwemiphumo emibi.
Isiphelo: Unyango oluthembisayo ukanti luyaphuhla
I-Cannabis inesithembiso esikhulu njengonyango lwe-asthma, kunye nee-cannabinoids ezifana ne-THC, i-CBD, kunye ne-CBG ebonisa amandla okunciphisa iimpawu, ukunciphisa ukudumba, kunye nokuphucula ukusebenza kwemiphunga. Ngelixa uphando kule ndawo lusaqhuba, ubungqina ukuza kuthi ga ngoku bubonisa ukuba i-cannabis inokuba lunyango olusebenzayo lwe-asthma, ngakumbi xa unyango lwesintu lungaboneleli ngokukhululeka ngokwaneleyo.
Noko ke, njengalo naluphi na unyango olutsha, kufuneka kulumke. Izigulana zombefu ezithathela ingqalelo i-cannabis njengenxalenye yerejimeni yonyango kufuneka ziqhagamshelane nababoneleli bazo bezempilo ukuze baqinisekise ukhuseleko kunye nokusebenza kwayo. Njengoko umzimba wophando usanda, ukusetyenziswa kwe-cannabis kwi-asthma kunokuba yinto eqhelekileyo kwaye isekwe kakuhle ekulawuleni le meko ingapheliyo yokuphefumla.
Comments