Introduction
Mescaline or mescalin (3,4,5-trimethoxyphenethylamine) is a naturally occurring psychedelic protoalkaloid of the substituted phenethylamine class, known for its hallucinogenic and neurological healing effects comparable to those of LSD and psilocybin.
What is Mescaline?
Mescaline can be isolated from any of the cactii listed below simply by taking off the outer skin and boiling the cactus in water until a thick, syrupy juice is obtained which can be drunk. It tastes terribly bitter and so a gum which can be swallowed in small amounts without tasting too much of it, is advisable. Micro-dosing with Mescaline is very popular because of the benefits achieved from taking mescaline in small doses.
Sources of Mescaline.
Plant source
Amount of Mescaline (% of dry weight)
Echinopsis lageniformis (Bolivian torch cactus, syns. Echinopsis scopulicola, Trichocereus bridgesii)[4]
0.25-0.56; 0.85 under its synonym Echinopsis scopulicola[5]
Leucostele terscheckii (syns Echinopsis terscheckii, Trichocereus terscheckii)[6]
0.01-5.5[10]
Trichocereus macrogonus var. macrogonus (Peruvian torch, syns Echinopsis peruviana, Trichocereus peruvianus)[11]
Trichocereus macrogonus var. pachanoi (San Pedro cactus, syns Echinopsis pachanoi, Echinopsis santaensis, Trichocereus pachanoi)[12]
Trichocereus uyupampensis (syn. Echinopsis uyupampensis)
0.05[5]
Is Mescaline legal?
While mescaline-containing cacti of the genus Echinopsis are technically controlled substances under the Controlled Substances Act, they are commonly sold publicly as ornamental plants.
In America Mescaline is legal for certain religious groups (such as the Native American Church by the American Indian Religious Freedom Act of 1978) and in scientific and medical research.
AU: S9 (Prohibited substance)
BR: Class F2 (Prohibited psychotropics)[1]
CA: Schedule III
DE: Anlage I (Authorized scientific use only)
UK: Class A (Plants containing mescaline legal)
US: Schedule I
UN: Psychotropic Schedule I
In South Africa the law is unclear on whether or not mescaline is legal as it classifies as a Traditional Medicine when used for Spiritual purposes.
Uses & Benefits.
Mescaline is Non-addictive.
Mescaline has a wide array of suggested medical usage, including treatment of alcoholism[5], addictions, depression.[6], Anxiety, Schizophrenia and Spiritual Transformation.
However, its status as a controlled substance in the Convention on Psychotropic Substances limits availability of the drug to researchers. Because of this, very few studies concerning mescaline's activity and potential therapeutic effects in humans have been conducted since the early 1970s.
Peyote has been used for at least 5,700 years by Indigenous peoples of the Americas in Mexico.[7] Europeans noted use of peyote in Native American religious ceremonies upon early contact,8] notably by the Huichols in Mexico. Other mescaline-containing cacti such as the San Pedro have a long history of use in South America, from Peru to Ecuador.[9,10,11,12] While religious and ceremonial peyote use was widespread in the Aztec empire and northern Mexico at the time of the Spanish conquest, religious persecution confined it to areas near the Pacific coast and up to southwest Texas. However, by 1880, peyote use began to spread north of South-Central America with "a new kind of peyote ceremony" inaugurated by the Kiowa and Comanche people. These religious practices, incorporated legally in the United States in 1920 as the Native American Church, has since spread as far as Saskatchewan, Canada.[7]
In traditional peyote preparations, the top of the cactus is cut off, leaving the large tap root along with a ring of green photosynthesizing area to grow new heads. These heads are then dried to make disc-shaped buttons. Buttons are chewed to produce the effects or soaked in water to drink. However, the taste of the cactus is bitter, so contemporary users will often grind it into a powder and pour it into capsules to avoid having to taste it.
Micro-dosing
The usual human dosage is 200–400 milligrams of mescaline sulfate or 178–356 milligrams of mescaline hydrochloride.[13,14] The average 76 mm (3.0 in) peyote button contains about 25 mg mescaline.[15]
One Dose of Mescaline Gum is 25 – 30 cm of cactus.
Micro-dose is 1/10th of a dose daily depending on the severity of the problem one can escalate to 3 micro-doses per day.
How Mescaline works.
In humans, mescaline acts similarly to other psychedelic agents.[1] It acts as an agonist,[2] binding to and activating the serotonin 5-HT2A receptor with a high affinity.[3] How activating the 5-HT2A receptor leads to psychedelia is still unknown, but it is likely that somehow it involves excitation of neurons in the prefrontal cortex.[4] Mescaline is also known to have even greater binding affinity for the serotonin 5-HT2C receptor.
Conclusion
Mescaline is a wonderful substance to experience Spiritual Transformation on. It is gentle on the mind and is perfectly suited for those with fragile minds, such as schizophrenia. It’s success with addiction is remarkable but much more scientific research needs to be done.
Sources:
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2. ^ Appel JB, Callahan PM (January 1989). "Involvement of 5-HT receptor subtypes in the discriminative stimulus properties of mescaline". European Journal of Pharmacology. 159 (1): 41–46. doi:10.1016/0014-2999(89)90041-1. PMID 2707301.
3. ^ Monte AP, Waldman SR, Marona-Lewicka D, Wainscott DB, Nelson DL, Sanders-Bush E, Nichols DE (September 1997). "Dihydrobenzofuran analogues of hallucinogens. 4. Mescaline derivatives". Journal of Medicinal Chemistry. 40 (19): 2997–3008. CiteSeerX 10.1.1.690.9370. doi:10.1021/jm970219x. PMID 9301661.
4. Béïque JC, Imad M, Mladenovic L, Gingrich JA, Andrade R (June 2007). "Mechanism of the 5-hydroxytryptamine 2A receptor-mediated facilitation of synaptic activity in prefrontal cortex". Proceedings of the National Academy of Sciences of the United States of America. 104 (23): 9870–9875. Bibcode:2007PNAS..104.9870B. doi:10.1073/pnas.0700436104. PMC 1887564. PMID 17535909.
5. "Could LSD treat alcoholism?". abcnews.go.com. 9 March 2012. Retrieved 5 October 2012.
6. ^ "Magic Mushrooms could treat depression". news.discovery.com. 23 January 2012. Retrieved 9 January 2013.
7. El-Seedi HR, De Smet PA, Beck O, Possnert G, Bruhn JG (October 2005). "Prehistoric peyote use: alkaloid analysis and radiocarbon dating of archaeological specimens of Lophophora from Texas". Journal of Ethnopharmacology. 101 (1–3): 238–242. doi:10.1016/j.jep.2005.04.022. PMID 15990261.
8. ^ Ruiz de Alarcón H (1984). Treatise on the Heathen Superstitions that Today Live Among the Indians Native to this New Spain, 1629. University of Oklahoma Press. ISBN 978-0806120317.
9. ^ Socha DM, Sykutera M, Orefici G (1 December 2022). "Use of psychoactive and stimulant plants on the south coast of Peru from the Early Intermediate to Late Intermediate Period". Journal of Archaeological Science. 148: 105688. doi:10.1016/j.jas.2022.105688. ISSN 0305-4403. S2CID 252954052.
10. ^ Bussmann RW, Sharon D (November 2006). "Traditional medicinal plant use in Northern Peru: tracking two thousand years of healing culture". Journal of Ethnobiology and Ethnomedicine. 2: 47. doi:10.1186/1746-4269-2-47. PMC 1637095. PMID 17090303.
11. ^ Armijos C, Cota I, González S (February 2014). "Traditional medicine applied by the Saraguro yachakkuna: a preliminary approach to the use of sacred and psychoactive plant species in the southern region of Ecuador". Journal of Ethnobiology and Ethnomedicine. 10: 26. doi:10.1186/1746-4269-10-26. PMC 3975971. PMID 24565054.
12. ^ Samorini, Giorgio (1 June 2019). "The oldest archeological data evidencing the relationship of Homo sapiens with psychoactive plants: A worldwide overview". Journal of Psychedelic Studies. 3 (2): 63–80. doi:10.1556/2054.2019.008.
13. ^ "#96 M – Mescaline (3,4,5-Trimethoxyphenethylamine)". PIHKAL. Erowid.org. Retrieved 7 September 2011.
14. ^ Uthaug MV, Davis AK, Haas TF, Davis D, Dolan SB, Lancelotta R, et al. (March 2022). "The epidemiology of mescaline use: Pattern of use, motivations for consumption, and perceived consequences, benefits, and acute and enduring subjective effects". Journal of Psychopharmacology. 36 (3): 309–320. doi:10.1177/02698811211013583. PMC 8902264. PMID 33949246.
15. ^ Giannini AJ, Slaby AE, Giannini MC (1982). Handbook of Overdose and Detoxification Emergencies. New Hyde Park, NY.: Medical Examination Publishing Company. ISBN 978-0-87488-182-0.
16. Finding medical value in mescaline - PubMed (www.ncbi.nlm.nih.gov)
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